Anti-D–mediated RBC clearance is easily detected in NOD-scid mice.

Groups of 3 NOD-scid mice were injected with 10 mg human IgGs only (○), or in the presence of 5 μg intact anti-D (■) or 5 μg F(ab′)2 fragments of polyclonal anti-D (▪). RBCs were prepared and injected as in Figure 1. RBC survival was measured as described in “Materials and methods.”