Activation-induced cell death of EBV-specific CD8⁺ cells after CD3/IL-2 versus CD3/CD28/IL-2 activation.

PBMCs were cultured for 3 days in the absence (dashed line, open symbol) or in the presence of CD3 /IL-2 (full line, closed symbol) or CD3/CD28/IL-2 (dashed line, closed symbol) activation. The percentage of annexin V⁺ cells is indicated for tetramer⁺CD8⁺ cells. Data are from 1 of 3 representative experiments.