Increased vascular remodeling in the inflamed skin of TSP-2–deficient mice.

Computer-assisted morphometric analysis of CD31-stained tissue sections revealed a moderately increased average vessel size at 24 hours after oxazolone challenge with normalization after 48 hours in the ear skin of wild-type mice (■). In contrast, cutaneous vessels in the inflamed skin of TSP-2–deficient mice (▪) were significantly larger after 24 hours, and the increase in vessel size persisted over 28 days. Data are expressed as mean ± SD. *P < .05; **P < .01.