Clot weights in normal blood and congenital hemophilia A blood initiated by TF.

Clots were obtained from blood to which 12.5 pM TF was added, according to the procedure described by Brummel et al.47 Bar 1 represents a composite of 11 experiments in normal blood; bar 2, a composite of 2 experiments in congenital hemophilia A blood; bar 3, a composite of 2 experiments contemporaneous to those in bar 2 when 10 and 50 nM factor VIIa was added to congenital hemophilia A blood; and bar 4, a contemporaneous control when 0.7 nM factor VIII was added to congenital hemophilia A blood.