Fig. 1.
Factor VIIa titration in a synthetic blood coagulation model in a complete system.
Thrombin generation was initiated either by 25 pM TF in the presence of factors V, VIII, VII, VIIa, IX, and X, prothrombin, AT-III, and TFPI at physiologic concentrations (▪) or by factor VIIa at 10 (▴), 20 (●), 30 (♦), 60 (■), and 120 nM (○) in the absence of TF. The reaction was conducted in the presence of either 2 μM PCPS (A) or 2 × 108/mL platelets (B).
