Lack of effect of SDF-1 administration on level of engraftment of NOD/SCID mice with human cells.

■, control mice injected with medium; ▪, SDF-1–treated mice. Values are the mean ± SEM of the total number of human cells of each type shown measured in 4 experiments. In each of these experiments, groups of 2 to 4 mice were injected with cord blood cells pooled from 1 to 3 donors and were then each injected 6 to 8 weeks later with 10 μg SDF-1 (or PBS) per mouse on 2 consecutive days prior to being killed and assessed on the third day. No significant difference (P > .05) was observed between the level of human cells in the control and SDF-1–treated animals for any of the human cell types examined.