Median values of plasma levels.

VWF:RCof (circles, dash-dot lines) and FVIII:C (triangles, solid lines) (A) and of bleeding times (squares, short dash lines) (B) before and after administration of A-SD (open symbols) and A-SD/HT (closed symbols), 60 IU/kg VWF:RCof, in 11 patients with type 3 VWD. Before treatment, median plasma levels of VWF:RCof, FVIII:C, and VWF:Ag were very low or were below detection, and bleeding times were longer than 30 minutes. Plasma levels shown at baseline reflect the lower limits of detection.