Therapy on CCG-1891.
Eligible enrolled patients were randomized at study entry to receive standard therapy with 1 delayed intensification phase (DI); standard therapy with 2 delayed intensification phases (DDI); or standard therapy with 1 delayed intensification phase and intensified vincristine and prednisone pulses during maintenance (DIVPI). Cumulative doses of anthracyclines were 75 mg/m2 in DI and DIVPI and 150 mg/m2 in DDI, and cumulative doses of cyclophosphamide were 1000 mg/m2 in DI and DIVPI and 2000 mg/m2 in DDI. There were 15 doses of L-asparaginase in DI and DIVPI and 21 in DDI. There were 8 doses of cytarabine at 75 mg/m2 in DI and DIVPI and 16 in DDI. DI prescribed 31 doses of 1.5 mg/m2 of vincristine for girls and 43 for boys; DIVPI, 41 doses for girls and 57 for boys; DDI, 34 doses for girls and 47 for boys. In DI, excluding tapers, there were 138 days of corticosteroid for girls and 198 for boys; in DIVPI, 188 days for girls and 268 for boys; and in DDI, 159 days for girls and 219 for boys. VCR indicates vincristine; PDN, prednisone; L-ASP, L-asparaginase; IT-MTX, intrathecal methotrexate; MP, mercaptopurine; MTX, methotrexate; DEX, dexamethasone; DOX, doxorubicin; CPM, cyclophosphamide; TG, thioguanine; ARA-C, cytosine arabinoside; *, total duration of therapy was 2 years for girls and 3 years for boys on all regimens; **, pulses given every 4 weeks; and #, pulses given every 3 weeks.
