Levels of sEPCR respond to warfarin in healthy adult volunteers.

Warfarin was administered to 6 adult volunteers for 8 days. The sEPCR levels (A), INR values (B), and F1 + 2 levels (C) were determined in blood drawn just before warfarin administration (day 0), throughout the administration period, and during a 1-week follow-up period. Data from each individual donor are indicated. The F1 + 2 levels are shown with the median, interquartile ranges, and 95% confidence intervals for the means.