FucS-induced mobilization occurs in the absence of metalloproteases.

(A) Total numbers of WBCs (circles), CFCs (bars), and SDF-1α levels (solid squares and heavy lines) in PB of wild-type or MMP9^−/− mice before (open circles and bars) or 2 hours after one intravenous injection of 100 mg/kg FucS (closed circles and bars) in the absence or presence of metalloprotease inhibitors; n = 3 animals per group. MMP9^−/− and wild-type data are representative of 3 separate experiments. All values after treatment were statistically significant to pretreatment values (WBCs and CFCs,P < .05 to P < .005; SDF-1,P < .000 001).