Fig. 1.
Fig. 1. Phylogenetically conserved sequences in the β-globin promoter and the HS2. / (A) Conservation of the −112 to −140 bp region from the transcription start site of the adult human β-globin promoter. The conserved sequences are underlined. The number at the left-hand side of the human sequence is the nucleotide number from the human globin locus (GenBank locus HUMHBB). (B) Comparison of the HS2 sequences at the NF-E2 region from mouse to human. The tandem NF-E2/AP1 sequences are double underlined. The numbers at the left-hand side of the sequences are the nucleotide numbers assigned to the respective globin locus. (C) Homology between the −112 to −139 bp β-promoter sequence (PCS) and the NF-E2 site (HS2-CS) of the HS2. The homologous sequences are underlined.

Phylogenetically conserved sequences in the β-globin promoter and the HS2.

(A) Conservation of the −112 to −140 bp region from the transcription start site of the adult human β-globin promoter. The conserved sequences are underlined. The number at the left-hand side of the human sequence is the nucleotide number from the human globin locus (GenBank locus HUMHBB). (B) Comparison of the HS2 sequences at the NF-E2 region from mouse to human. The tandem NF-E2/AP1 sequences are double underlined. The numbers at the left-hand side of the sequences are the nucleotide numbers assigned to the respective globin locus. (C) Homology between the −112 to −139 bp β-promoter sequence (PCS) and the NF-E2 site (HS2-CS) of the HS2. The homologous sequences are underlined.

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