Genomic map of the region surrounding the

int1h repeats in Xq28.Int1h repeats are shown as black boxes. Only the first 6 exons of factor VIII and first 3 exons of VBP1 are shown, with arrows indicating direction of transcription. Hatched boxes indicate facultative exons spliced into chimeric mRNAs of patients with int1h-related inversions. Exons A, B, 1, 2, 3, and 4 represent seq 29A, seq 29B, 45 bp, 30 bp, 100 bp, and 142 bp exons, respectively.8,28 Size bars indicate the location and extent of DNA sequence contigs constructed from entries in GenBank human DNA sequence database.