Fig. 2.
Fig. 2. cux/CDPΔHD/ΔHD mice have pleiotropic abnormalities. / (A) Comparison of 14-day-old male littermates heterozygous (right) and homozygous (left) for the cux/CDPΔHD allele. (B) Comparative graph of the relationship between age and weights of wild-type/heterozygous (CT) and homozygous (ΔHD) littermates aged between 10 and 37 days. Comparison of thymus (C) and (D) hind leg sizes fromcux/CDPΔHD/ΔHD and control littermates. Arrow indicates reduced size of calf muscle. (E) Histologic comparisons of cux/CDPΔHD/ΔHD(ΔHD) andcux/CDP+/ΔHD (CT) thymus, femur (arrowheads show bone fragmentation), and skin (bars show thickness of subcutaneous fat); c indicates cortex; m, medulla; bm, bone marrow; scf, subcutaneous fat. Magnification 100 ×.

cux/CDPΔHD/ΔHD mice have pleiotropic abnormalities.

(A) Comparison of 14-day-old male littermates heterozygous (right) and homozygous (left) for the cux/CDPΔHD allele. (B) Comparative graph of the relationship between age and weights of wild-type/heterozygous (CT) and homozygous (ΔHD) littermates aged between 10 and 37 days. Comparison of thymus (C) and (D) hind leg sizes fromcux/CDPΔHD/ΔHD and control littermates. Arrow indicates reduced size of calf muscle. (E) Histologic comparisons of cux/CDPΔHD/ΔHD(ΔHD) andcux/CDP+/ΔHD (CT) thymus, femur (arrowheads show bone fragmentation), and skin (bars show thickness of subcutaneous fat); c indicates cortex; m, medulla; bm, bone marrow; scf, subcutaneous fat. Magnification 100 ×.

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