Cyclosporin inhibits induction of TF activity and protein by OxPAPC.

HUVECs were pretreated with indicated concentrations of cyclosporin A for 20 minutes and then stimulated for 6 hours with 125 μg/mL OxPAPC in the presence of the inhibitor. Cells were scraped off and analyzed by clotting assay or Western blotting using antibodies to TF. Similar results were obtained in 2 additional experiments.