Fig. 3.
![Fig. 3. Effect of P2 receptor antagonists or SC57101 on ADP-induced arachidonic acid liberation. / Washed human platelets, loaded with [3H]-arachidonic acid, were activated with ADP (10 μM) plus fibrinogen at 37°C with stirring in the presence or absence of A3P5P, AR-C66096, or SC57101, a fibrinogen receptor antagonist. Arachidonic acid (AA) plus metabolites in the supernatant was measured as described in “Materials and methods.” The radioactivity in the unstimulated total platelets (0.5 mL) was taken as 100%, and the data were normalized to this value. The data are derived from at least 3 independent experiments in triplicate and analyzed as in Figure 1. NS indicates not statistically significant. *P < .05. **P < .025.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/1/10.1182_blood.v99.1.193/6/h80121929003.jpeg?Expires=1722617462&Signature=AyN-LsIRNjce3igJFQ9~wIilnkyePrxUqpg8GP4N-fkoRUu~ZnLO93BG2Js-glM7kqqzMDHiFIFJbdwquV0sk967i9y-ArrD3Pla8pAqjdHC9HAyNac3ixYno~UhgaoJsZa9Hj2cWpV2S1ZOioE~cMRLvov5G~-t8N-iDzq5pQa~m54PJPFrUZgxeQ1CiQar5rKn8MRFolrMVTWBoYxUykOeRoAFnwHxEfge1kLGG2SIwwJJJvWg3AdNrSblDwwOdii0mSeJv6ZJgCsNPgaiK3tz2dMJ7a7M8bah5W5Sm0DjR5uEk3eoLHkA0H91W9O5ZMItsB7MGHUELLBDoeiMLA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of P2 receptor antagonists or SC57101 on ADP-induced arachidonic acid liberation.
Washed human platelets, loaded with [3H]-arachidonic acid, were activated with ADP (10 μM) plus fibrinogen at 37°C with stirring in the presence or absence of A3P5P, AR-C66096, or SC57101, a fibrinogen receptor antagonist. Arachidonic acid (AA) plus metabolites in the supernatant was measured as described in “Materials and methods.” The radioactivity in the unstimulated total platelets (0.5 mL) was taken as 100%, and the data were normalized to this value. The data are derived from at least 3 independent experiments in triplicate and analyzed as in Figure 1. NS indicates not statistically significant. *P < .05. **P < .025.
