Adhesion efficiency.
(A) Number of adherent (> 30 seconds) leukocytes/mm2. Closed bars indicate low shear venules (200-500 s−1); open bars, high shear venules (500-1000 s−1). (B) Systemic leukocyte counts measured in TNF-α–treated mice. Dotted, PMN, striped, mononuclear cells. (C) Overall adhesion efficiency. The number of adhered leukocytes/mm2 was normalized by the systemic leukocyte counts to determine overall adhesion efficiency. Closed bars represent low shear rate range (200-500 s−1); open bars represent high shear rate range (500-1000 s−1). Data presented as mean ± SEM. Significant differences between shear rate groups indicated by brackets in panel A and differences from wild-type mice indicated by asterisk in panels B and C (P < .05). Table 1 lists numbers of mice and venules.
