Differences in cellular resistance between DS AML and DS ALL for (A) cytarabine (Ara-C) and daunorubicin (DNR), (B) idarubicin (Ida) and mitoxantrone (Mitox), (C) vincristine (VCR) and prednisolone (Pred), (D) L-asparaginase (L-ASP) and 6-thioguanine (6-TG), and (E) MTX (after short-term exposure and after continuous exposure).

The median LC₅₀ value is depicted as a horizontal solid line, and the 25th and 75th percentiles are depicted as triangles. DS AML cells are significantly more sensitive to cytarabine (median, 21-fold) than DS ALL cells. For 6-thioguanine there was a trend suggesting that DS AML was more sensitive than DS ALL (median, 2.7-fold), and for prednisolone there was a trend suggesting that DS ALL cells are more sensitive than DS AML cells (median, almost 2000-fold). DS AML cells were significantly more resistant than DS ALL cells after short-term exposure to methotrexate (median, 113-fold); however, this was not the case after continuous methotrexate exposure. For the other drugs, no significant differences were found.