Determination of sHbSR in plasma of hematological patients.

(A) Determination of sHbSR in plasma of hematological patients by sandwich ELISA with polyclonal anti-HbSR used as capture-antibody and with monoclonal anti-CD163 antibody (GHI/61) used as detector antibody. Concentration of sHbSR in controls (CTRL) (n = 130) and hematological patients (n = 140) with various diagnoses. LYM indicates lymphoma; MM, myeloma; LL, lymphatic leukemia; ML, myelomonocytic leukemia; AN, anemia from various causes (hemolytic anemia, aplastic anemia, iron-deficiency anemia, vitamin B12–deficiency anemia, sickle cell anemia, and thalassemia); MISC, miscellaneous hematological diagnosis (malignant histiocytosis, myelodysplasia, lymphocytosis, essential thrombocytosis, polycytemia, amyloidosis). The right column (INF) shows the sHbSR values in the hematological patients with infections (pneumonia/sepsis). Solid lines indicate 2.5 and 97.5 percentiles of the log-Gauss–transformed distribution of the sHbSR values in blood donors. (B) Patient with newly diagnosed AML type M4 and in chemotherapy. The patient developed an infection on day 14. Solid line indicates 97.5 percentile of blood donors.