Expression of

Dll4 in lymphoma cells. Immunohistochemistry staining liver section from a Dll4-overexpressing animal (no. 21) with anti-CD3 antibody at 10.5 weeks after BMT (panel A). Results from in situ hybridization with antisense neo(panel B) and Dll4 (panel C) are shown in dark field view. Proviral junction analysis (panel D) of DNA from spleens of a normal mouse (−) and mouse no. 21 digested withSpeI shows that the animal contained one major (a) and one minor clone (b).