Ex vivo BM specimens obtained from patients with MM overexpress OPGL mRNA in comparison with those from healthy donors.

All BM mononuclear cells were cultured for 2 weeks, and the expression of mRNA was assessed in adherent cells by semiquantitative RT-PCR analysis in BM samples obtained from MM patients with osteolytic lesions (MM1, MM2, MM3) in comparison with BM samples from healthy donors (N1 and N2).