The inhibitory effect of XG-6 on OPG secretion in coculture involves cell-to-cell contact.

Effect of XG-6 on OPG production in coculture system in the presence of a tissue insert in a transwell system (A) or in the presence of VLA-4 mAb compared with an IgG control (B). Aliquots of conditioned media were assessed for OPG concentration by ELISA. Graphics represent the mean levels ± SE of 6 repeated experiments. *P = .01; **P = .001.