Fig. 6.
Three-dimensional representations of platelet deposition from whole blood onto vWf–collagen 1 after 60 seconds of perfusion at 3000 s−1.
Images were acquired in the presence of (A) saline (control), (B) 0.5 μM ARMX, (C) 10 μM A3P5P, (D) 5 μg/mL abciximab, and (E) 0.5 μM ARMX + 10 μM A3P5P. Images were digitized, and 3-dimensional structures were inferred from their 2-dimensional structures. Fluorescence intensity is proportional to the platelet number; therefore, the height of the thrombus is proportional to the intensity of the image at any point within the thrombus.28
