Fig. 7.
![Fig. 7. Inhibition of chemotaxis by truncated IP-10(3-77) and I-TAC(3-73). / The antagonistic activity of CD26/DPP IV–truncated IP-10 and I-TAC was tested on CXCR3-transfected cells in the Boyden microchamber. Intact agonistic IP-10 or I-TAC (at 10 or 30 nM) was added with or without 30 nM truncated chemokine [IP-10(3-77) or I-TAC(3-73)] to the bottom well of the chemotaxis chamber. Results represent the mean (± SEM) percent inhibition of the chemotactic index (CI) toward intact chemokine alone from 4 to 5 independent experiments. The Studentt test was used for statistical analysis comparing the CI with and without addition of truncated chemokine (** = P < .05; *** = P < .01).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/98/13/10.1182_blood.v98.13.3554/6/h82411847007.jpeg?Expires=1722777499&Signature=trku1ScZE2snVKrmydjw6YVvQ-cbhl~bL2ziZd1bmzGHubjEdRAg70xUXr4GmK9QM5XRXYET0iZwT0oNZImQEev~oxFRbd4kpxNnUyyQ0sUr8WPVS8ONalfufD8y65AO1Tvq0a3o8uFLdg24XxN8QHCiMbYl5ZWd01fSA1H0Al-n7hgnc9xb7rWpckZYayDHv5Xao5qDxxu~rCNGUS1Vm7oQ8x2Gbr3Ck7dO5fykUTrUEvVwk--Rl6EVwyYuj3rWT-pqK9f9BQStEsQVGzOYsfhqHTKp~gv5BHxTqrmsSHLQRBD36JBYlj64OYZjGon4UrRy6zgiWGG~K4hrm1ib0A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of chemotaxis by truncated IP-10(3-77) and I-TAC(3-73).
The antagonistic activity of CD26/DPP IV–truncated IP-10 and I-TAC was tested on CXCR3-transfected cells in the Boyden microchamber. Intact agonistic IP-10 or I-TAC (at 10 or 30 nM) was added with or without 30 nM truncated chemokine [IP-10(3-77) or I-TAC(3-73)] to the bottom well of the chemotaxis chamber. Results represent the mean (± SEM) percent inhibition of the chemotactic index (CI) toward intact chemokine alone from 4 to 5 independent experiments. The Studentt test was used for statistical analysis comparing the CI with and without addition of truncated chemokine (** = P < .05; *** = P < .01).
