Receptor binding properties of intact and CD26/DPP IV–truncated CXCR3 agonists on CXCR3-transfected cells.

Intact (filled symbols) and CD26/DPP IV–truncated (open symbols) IP-10 (diamonds), I-TAC (triangles), and Mig (circles) were tested for their ability to compete for ¹²⁵I-labeled I-TAC binding to CXCR3-transfected CHO cells. Results represent the mean (± SEM) percent of ¹²⁵I-I-TAC that binds to the cells compared to the amount of labeled I-TAC that binds the cells without addition of cold ligands (3 or more independent experiments). The Studentt test was used for statistical analysis (** = P < .05 and *** = P < .01 for a significant difference between the intact and truncated chemokines).