Comparison of the chemotactic activity of intact and truncated chemokines on CXCR3-transfected cells.

Met-IP-10 (filled squares), intact (filled symbols), and CD26/DPP IV–truncated (open symbols) IP-10 (diamonds), Mig (circles), and I-TAC (triangles) were tested for their ability to induce a chemotactic response on CXCR3-transfected CHO cells. Results represent the mean (± SEM) chemotactic index of 4 or more independent experiments. The Student t test was used for statistical analysis (* = P < .1; ** = P < .05; *** = P < .01 for a positive chemotactic response compared to buffer controls).