Effect of CD26/DPP IV on the lymphocyte chemotactic activity of IP-10.

The chemotactic activity of Met-IP-10 (filled squares), intact (filled diamonds), and CD26/DPP IV–truncated (open diamonds) IP-10 for PHA-stimulated (A) or anti-CD3–stimulated (B) lymphocytes was measured in the Boyden chamber assay. Results represent the mean (± SEM) chemotactic index of 4 or more independent experiments with cells from different donors. The Student ttest was used for statistical analysis (* = P < .1; ** = P < .05; *** = P < .01 for a significantly positive chemotactic response compared to buffer controls).