Response to STI571 and SU5402.

Response of BaF3/BCR-ABL (A) and representative ZNF198-FGFR1 (B) and BCR-FGFR1 (C) clones to 5 μM STI571 or 10 μM SU5402. (D) Dose response of a representative ZNF198-FGFR1 clone to increasing amounts of SU5402. (E) Increasing concentrations of SU5402 added to a representative ZNF198-FGFR1 clone result in deceasing levels of tyrosine phosphorylated fusion protein and phospho ERK. Total protein levels are unchanged, as indicated by probing with anti-MEK.