A rescued immunoglobulin from an HCV-associated lymphoma reacts with HCV-E2 from multiple genotypes.

Anti-E2 mAb CBH-4G (░), HCV-associated immunoglobulin patient 2 (▪), and HCV-associated immunoglobulin patient 1 (▧) were added to wells coated with E2, obtained from cells infected with recombinant vaccinia virus expressing the recombinant protein from HCV genotypes 1a (Q1a), 1b (Q1b), 2a (Q2a), and 2b (Q2b) or with vaccinia wild-type virus (VWA). Bound immunoglobulin was determined by ELISA. Error bars indicated 1 SD from the mean.