Fancg ^−/− mice have germ cell defects and decreased fertility.

(A) Histology of mutant and control ovaries (hematoxylin and eosin staining). Ovary of an 8-week-old mutant or control mouse. The mutant ovary was almost completely devoid of follicles (iii, × 60; iv, × 125). The control ovary had an abundance of developing follicles at various stages (i, × 60; ii, × 125). (B) Histology of mutant and control testis (hematoxylin and eosin staining). A mosaic pattern of seminiferous tubules devoid of germ cells and normal tubules can be seen in the mutant testis (iv, × 250; v and vi, × 320). A control testis is shown at the same magnification (i, ii, iii). Arrows indicate Sertoli cells.