Differential IR sensitivity of

Fancg^+/− andFancg^−/− primary splenic lymphocytes. (A) Analysis of chromosome breakage following exposure to variable amounts of IR. Results shown are representative of 3 separate experiments. (B) Analysis of cell viability by the trypan blue assay following IR exposure. Based on this assay, theFancg^+/− and Fancg^−/−cells had approximately equal viability (95%-98% viable) in the absence of IR exposure. Data shown are representative of 3 separate experiments.