CD4⁺ and CD8⁺ cells proliferate more rapidly in semiallogeneic than in syngeneic irradiated hosts.

CFSE-labeled T cells from hCD4 transgenic B6 mice were transferred into semiallogeneic (B6/D2) or syngeneic (B6) lethally irradiated mice. Data show proliferation (as examined by CFSE dilution pattern) of donor (hCD4⁺ gated) CD4⁺ and CD8⁺ T cells recovered from spleen of recipient mice at 3 different time points (40, 64, and 88 hours) following transfer. Similar results were obtained for 3 allogeneic and 3 syngeneic recipient mice at each time point.