Effect of TRAIL on in vitro hemopoiesis.

(A) In vitro colony formation (CFU-GM) from normal (Normal) and MDS marrow, with all cases combined (All MDS), and less advanced and advanced MDS shown separately. For each group, the left column indicates results without TRAIL exposure, and the right column with TRAIL exposure (mean ± SE). Marrow from 6 healthy donors and 21 patients with MDS, 11 less advanced (RA; RARS, RAEB), and 10 advanced (RAEB-T/tAML; CMML) were studied. (B) Changes in colony formation for each group shown in part A, expressed relative to the respective control (marrow cells not exposed to TRAIL).