TRAIL-induced apoptosis in normal and MDS marrow cells.

The extent of apoptosis in normal and MDS marrow cells exposed to TRAIL at 0 to 1000 ng/mL for 12 hours was assessed by Annexin V staining and by way of DNA histograms (see “Materials and methods”). Shown are the mean values for normal marrow (n = 10) and for MDS marrow (n = 22); standard deviations ranged from ± 6% to ± 8% for normal, and ± 8% to ± 14% for MDS marrow.