Specificity of killing of CD40-activated B cells pulsed with native and heteroclitic peptides.

(A) Killing by T-cell lines generated against native peptide CDR16 of unpulsed CD40-activated B cells and CD40-activated B cells pulsed with heteroclitic peptide, native peptide, or control peptide (FR9) at the effector-to-target ratios shown. (B) Killing by T-cell lines generated against heteroclitic peptide CDR16H of unpulsed CD40-activated B cells and CD40-activated B cells pulsed with heteroclitic peptide, native peptide, or control peptide (FR9) at effector-to-target ratios shown. Results are mean ± SD values from experiments done in triplicate with samples from a single donor and are representative of results from experiments done with samples from 5 different donors.