Redox cycling of unmodified hemoglobin induces G2/M arrest and apoptosis.

(A) The proportion of G2/M cells measured after a 9-hour incubation with medium alone or medium containing 2 mU/mL GOX and 50 μM DBBF-Hb or unmodified hemoglobin. Each value represents the mean ± SE of 3 to 5 independent experiments. (B) PS externalization measured after 18 hours for the same treatments as in panel A. Each value represents the mean ± SE of 3 to 5 independent experiments.