Reversal of red cell abnormalities in AIHA following steroid therapy.

The osmotic deformability profiles (top panel) of blood samples from an individual with AIHA at the time of diagnosis (dashed lines) and following steroid therapy (solid line). The deformability profile of a representative normal blood sample is indicated by the thick line. Note the complete normalization of the deformability profile following treatment. Volume and cell hemoglobin concentration distribution histograms of red cells from the same individual with AIHA before and after steroid therapy. Note the complete disappearance of dehydrated red cells with cell hemoglobin concentration of more than 41 g/dL following steroid therapy.