Reticulocyte and red cell surface area in HS and AIHA.

Surface area of reticulocytes (left panel) and of mature red cells (middle panel) in blood samples from control individuals (n = 12) and individuals with HS (n = 12) or AIHA (n = 7). In HS samples, the surface area of both reticulocytes and mature red cells was decreased compared with controls (P  < .0001) whereas in AIHA samples, only the surface area of mature red cells (P = .0053), but not of reticulocytes, was decreased. The extent of difference in surface area between reticulocytes and mature red cells (ΔSA) was similar for HS and controls (right panel). In contrast, the difference in surface area between reticulocytes and mature red cells is larger in AIHA when compared with either normal cells (P = .0022) or with HS cells (P = .0084).