Splenomegaly in Stat5a^−/−5b^−/− mice correlates with their degree of anemia.

(A) Hematoxylin and eosin-stained sections of adult spleen from either wild-type or Stat5a^−/−5b^−/− mice. Thick arrow points at a region of red pulp. Thin arrow points at a region of white pulp. Photographs were taken at an original magnification of × 25. (B) Splenomegaly in Stat5a^−/−5b^−/−mice inversely correlates with both the hematocrit and hemoglobin concentration. Correlation curve was fitted using Microsoft Excel Trendline tool to the Stat5a^−/−5b^−/− adult data, excluding one data point from an extremely anemic mouse (in brackets). The curves drawn fit the equations y = 3487 × ^−2.4 (R² = 0.91) for the hemoglobin data, and y = 12 089 × ^−2.0(R² = 0.72) for the hematocrit data.