Simulation of the effect of IVIG administration to humans on IgG autoantibody levels in the plasma.

For the upper panel, the dose was 2 × 1 g/kg body weight on 2 consecutive days; for the lower panel, it was 5 × 0.4 g/kg body weight on 5 consecutive days. Upper bold lines represent autoantibody levels (percentage of control), middle lines represent the total IgG plasma concentration (mg/mL), and lower lines represent the FCRs (percentage of the intravascular pool per day).