Fig. 1.
Fig. 1. Neutrophilia in CD18−/− mice is not caused by neutrophil accumulation in the systemic circulation. / (A) Lethally irradiated wild-type (WT) mice underwent transplantation with wild-type, CD18−/−, or a 10:1, 1:1, or 1:10 mixture of bone marrow. Relative amounts of CD18+/+ and CD18−/− neutrophils in the systemic microcirculation were followed by flow cytometry. The percentages of CD18−/−neutrophils in the circulation at 4.5, 6.0, or 8.5 weeks corresponded to the relative concentrations of CD18−/− bone marrow that was transplanted. (B) Severe neutrophilia in CD18−/−mice was restored to normal by CD18+/+ neutrophils. *Significantly different from all other groups (P < .05). Data are expressed as mean ± SEM (n = 3). BMT indicates bone marrow transplantation; PMN, polymorphonuclear neutrophils.

Neutrophilia in CD18−/− mice is not caused by neutrophil accumulation in the systemic circulation.

(A) Lethally irradiated wild-type (WT) mice underwent transplantation with wild-type, CD18−/−, or a 10:1, 1:1, or 1:10 mixture of bone marrow. Relative amounts of CD18+/+ and CD18−/− neutrophils in the systemic microcirculation were followed by flow cytometry. The percentages of CD18−/−neutrophils in the circulation at 4.5, 6.0, or 8.5 weeks corresponded to the relative concentrations of CD18−/− bone marrow that was transplanted. (B) Severe neutrophilia in CD18−/−mice was restored to normal by CD18+/+ neutrophils. *Significantly different from all other groups (P < .05). Data are expressed as mean ± SEM (n = 3). BMT indicates bone marrow transplantation; PMN, polymorphonuclear neutrophils.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal