Translocation of

PDGFβR gene in patient-derived genomic DNA.Patient and normal control genomic DNA was restriction enzyme digested (BamHI, EcoRI, HindIII, andPvuII), electrophoretically separated, and transferred to a nitrocellulose membrane. Southern blotting was performed using a 1.1-kb (HindIII-XhoI fragment) genomic PDGFβR probe (see “Patient and methods”). Arrows indicate patient-specific bands, showing translocation involving the PDGFβRgene.