Effect of Mpl ligand on hematopoietic suppression and recovery in wild-type and

p53^−/− mice after lethal myelosuppression. The effects of PEG-rmMGDF administered immediately after carboplatin and γ-IR on platelet count (A), hemoglobin concentration (B), and WBC count (C), inp53^−/−mice (7 mice) and wild-type C57Bl/6J mice (7 mice). As controls, p53^−/−mice and wild-type mice (7 mice per group) were treated with carrier. Each point represents ± SEM. The trends were reproducible in 2 subsequent experiments.