Effects of a biotinylated polymeric, N-acetyl-galactosamine–containing CA on circulating 1F5-SA conjugate.

Six BALB/c mice were injected intraperitoneally with 1.4 nmol of the¹²⁵I-1F5 (anti-CD20)–streptavidin (SA) conjugate at time 0. Three mice were injected intraperitoneally 24 hours later with 5.8 nmol CA (bold line), whereas the other 3 mice did not receive CA (thin line). Serial blood samples were obtained from the retro-orbital venous plexus 6, 24, 24.5, 25, 26, 27, 28, 29, 48, 72, and 96 hours after the injection of ¹²⁵I-1F5-SA and were analyzed by gamma counting.