VEGF antisense MBOs.

(A) Schematic representation of the mixed backbone formulation oligonucleotides. Shown are the human VEGF gene sequence and complementary AS-3 sequences. The chemical structures of the modified bases are shown below. (B) Comparison of the corresponding areas of the VEGF family members: The highlighted bases indicate identity between VEGF-B, VEGF-C, VEGF-D, or PlGF and VEGF-A. Homology between the genes is not high in this region. (C) Comparison of the sequences in the human and mouse VEGF genes that are complementary to AS-3. The mouse sequence shown here is nucleotides 288 to 308 of the sequence reported by Claffey et al.60 Identity is indicated by highlighted blocks.