U937 cells adhered to FN for 2 hours were resistant to apoptosis induced by mitoxantrone and etoposide.

(A) Adhesion to FN significantly reduced mitoxantrone-induced apoptosis (P < .05 on ANOVA). Shown are the mean results and 95% confidence intervals (CIs) from 3 independent experiments done in duplicate (the percentage of apoptosis is equal to the percentage of apoptosis in drug-treated samples minus the percentage of apoptosis in the vehicle control). (B) Adhesion to FN significantly decreased etopside-induced apoptosis (P < .05 by ANOVA). Shown are the mean results and 95% CIs from 4 independent experiments done in duplicate (the percentage of apoptosis is equal to the percentage of apoptosis in drug-treated samples minus the percentage of apoptosis in the vehicle control).