Decreased resistance of NFAT1^−/−IL-4^−/− mice to infection with

L major. (A) NFAT1^−/−IL-4^−/− and NFAT1^+/+ IL-4^−/−female mice (10 mice per group) were infected with promastigotes ofL major in the left hind footpad. Footpad thickness was recorded at the indicated times using a metric caliper, and the lesion size was calculated as the difference between the injected and the uninjected footpads. Values are shown as means ± SD. (B) NFAT1^−/− IL-4^−/− and NFAT1^+/+IL-4^−/− mice (3 mice per group) were infected with promastigotes of L major as in panel A. Eleven weeks after infection, the number of parasites in the draining popliteal lymph nodes was determined as described in “Material and methods.” Values are shown as means ± SD. KO, knockout mice; DKO, double-knockout mice.