Heme oxygenase expression in liver and pancreas.

Liver (A-B) and pancreas (C-D) of BALB/c mice after 24-hour exposure to either saline (A, C) or heme (B,D) were assayed for the expression of HO-1 immunoreactive proteins (SPA895 antibody). HO-1 is hardly detectable in control animals but is highly induced after heme exposure in residing Kupffer cells (arrowhead) and (infiltrating) leukocytes (arrowhead) or lining cells (arrowhead).