MMC hypersensitivity.

Effect of alanine-substituted FANCC mutants on MMC sensitivity is shown in FA-C lymphoblast cell lines PD4 (A) and HSC536N (B) and normal lymphoblast cell line JY (C). Cells were treated with varying concentrations of MMC for 5 days before stained with trypan blue dye to quantify viable cells. Cell viability is expressed as percentages of viable cells relative to the untreated control culture. Each data point represents the mean ± SD of at least triplicate determinations.