Size comparison of atherosclerotic lesions in the aortic sinus of LDLR-deficient mice with and without vWf.

Eight-week-old mice were put on an atherogenic diet for 8 or 22 weeks. Hearts were collected and processed, and oil red-O–positive lesions were measured. Mean values of 5 sections per mouse were compared. Bars represent standard error of the mean. Differences between LDLR−/− vWf+/+ and LDLR−/−vWf−/− mice were significant at both time points.