Peptide concentration-dependent cytotoxicity and IFN-γ production of bcr-abl–specific CD4⁺ T-lymphocyte clones.

(A) Cytotoxicity of MY-1 and TO-1 against autologous (○) and HLA-DRB1*0901⁻ allogeneic (●) mature DCs preincubated with various concentrations of b3a2 peptide for 4 hours was determined by ⁵¹Cr release assays. (B) IFN-γ production by MY-1 and TO-1 stimulated with autologous (○) and HLA-DRB1*0901⁻allogeneic (●) mature DCs preincubated with various concentrations of b3a2 peptide for 4 hours was determined by ELISA.